Discovering Protein Receptors for Signaling Nucleotides

Discovering Protein Receptors for Signaling Nucleotides

Basic research is a journey taken by scientists to explore our fundamental understanding of biology. The process of conducting basic research leads to new solutions and knowledge that can be applied to different problems, including many unexpected ones. One of the primary questions I have been interested in since starting my journey, upon entering graduate school, is: how do bacteria detect cha...

Discovering Domains Mediating Protein Interactions

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

Discovering the interaction propensities of amino acids and nucleotides from protein-RNA complexes.

With the availability of many genome sequences, the mining of biological data is attracting much attention, most of it limited to the sequences of macromolecules. Sequence data are easy to analyze as they can be treated as strings of characters, whereas the structure of a macromolecule is much more complex. We developed a set of algorithms to analyze the structures of protein-RNA complexes at t...

Mitogenic signaling via G protein-coupled receptors.

discovering domains mediating protein interactions

background: protein-protein interactions do not provide any direct information re­garding the domains within the proteins that mediate the interactions. the majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. most of the former studies focus only on interacting do­main pairs. however they do not consider the interaction...